The human protein kinase gene PKX1 on Xp22.3 displays Xp/Yp homology and is a site of chromosomal instability.

@article{Klink1995TheHP,
  title={The human protein kinase gene PKX1 on Xp22.3 displays Xp/Yp homology and is a site of chromosomal instability.},
  author={Albrecht Klink and Katrin Schiebel and Martina Winkelmann and E. V. C. Sekhara Rao and Bernhard Horsthemke and H J L{\"u}decke and Uwe Claussen and Gerd Scherer and Gudrun A Rappold},
  journal={Human molecular genetics},
  year={1995},
  volume={4 5},
  pages={
          869-78
        }
}
We have isolated a gene, PKX1, by virtue of its position within the candidate region for chondrodysplasia punctata in Xp22.3. Although data from one patient render it unlikely that PKX1 is the CDPX gene, this gene shows several interesting features. First, PKX1 appears to encode a novel type of human protein kinase that is related to the catalytic subunit of cAMP-dependent protein kinases and has striking homology to the DC2 protein kinase from Drosophila melanogaster. Second, PKX1 is part of a… CONTINUE READING
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