The human polymeric immunoglobulin receptor binds to Streptococcus pneumoniae via domains 3 and 4.

@article{Lu2003TheHP,
  title={The human polymeric immunoglobulin receptor binds to Streptococcus pneumoniae via domains 3 and 4.},
  author={Ling Lu and Michael Lamm and Hongmin Li and Blaise Corthesy and Jing-Ren Zhang},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 48},
  pages={
          48178-87
        }
}
Streptococcus pneumoniae (the pneumococcus) is a major cause of bacterial pneumonia, middle ear infection (otitis media), sepsis, and meningitis. Our previous study demonstrated that the choline-binding protein A (CbpA) of S. pneumoniae binds to the human polymeric immunoglobulin receptor (pIgR) and enhances pneumococcal adhesion to and invasion of cultured epithelial cells. In this study, we sought to determine the CbpA-binding motif on pIgR by deletional analysis. The extra-cellular portion… CONTINUE READING

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