The human phosphatase interactome: An intricate family portrait

  title={The human phosphatase interactome: An intricate family portrait},
  author={Francesca Sacco and Livia Perfetto and Luisa Castagnoli and Gianni Cesareni},
  booktitle={FEBS letters},
The concerted activities of kinases and phosphatases modulate the phosphorylation levels of proteins, lipids and carbohydrates in eukaryotic cells. Despite considerable effort, we are still missing a holistic picture representing, at a proteome level, the functional relationships between kinases, phosphatases and their substrates. Here we focus on phosphatases and we review and integrate the available information that helps to place the members of the protein phosphatase superfamilies into the… CONTINUE READING
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