The human papillomavirus type 16 E5-protein modulates ligand-dependent activation of the EGF receptor family in the human epithelial cell line HaCaT.

@article{Crusius1998TheHP,
  title={The human papillomavirus type 16 E5-protein modulates ligand-dependent activation of the EGF receptor family in the human epithelial cell line HaCaT.},
  author={Kerstin Crusius and Eeva Auvinen and Barbara Steuer and Henning C Gaissert and {\'A}ngel Alonso},
  journal={Experimental cell research},
  year={1998},
  volume={241 1},
  pages={76-83}
}
The E5 open reading frame of the human papillomavirus type 16 encodes a transmembrane protein associated with the Golgi, ER, and plasma membranes. We have analyzed the effect of E5 expression on the activation of the EGF receptor family. We find that expression of the E5-protein strongly enhances EGFR activation in a ligand-dependent manner. This activation takes place immediately after addition of ligand, demonstrating that increased tyrosine phosphorylation cannot solely be due to an impaired… CONTINUE READING