The human papillomavirus type 16 E5 oncoprotein inhibits epidermal growth factor trafficking independently of endosome acidification.

@article{Suprynowicz2010TheHP,
  title={The human papillomavirus type 16 E5 oncoprotein inhibits epidermal growth factor trafficking independently of endosome acidification.},
  author={Frank A Suprynowicz and Ewa Krawczyk and Jess D Hebert and Sawali R Sudarshan and Vera Simic and Christopher M Kamonjoh and Richard Schlegel},
  journal={Journal of virology},
  year={2010},
  volume={84 20},
  pages={10619-29}
}
The human papillomavirus type 16 E5 oncoprotein (16E5) enhances acute, ligand-dependent activation of the epidermal growth factor receptor (EGFR) and concomitantly alkalinizes endosomes, presumably by binding to the 16-kDa "c" subunit of the V-ATPase proton pump (16K) and inhibiting V-ATPase function. However, the relationship between 16K binding, endosome alkalinization, and altered EGFR signaling remains unclear. Using an antibody that we generated against 16K, we found that 16E5 associated… CONTINUE READING