The human papillomavirus E7 oncoprotein.

  title={The human papillomavirus E7 oncoprotein.},
  author={Margaret E McLaughlin-Drubin and Karl M{\"u}nger},
  volume={384 2},
The human papillomavirus (HPV) E7 oncoprotein shares functional similarities with such proteins as adenovirus E1A and SV40 large tumor antigen. As one of only two viral proteins always expressed in HPV-associated cancers, E7 plays a central role in both the viral life cycle and carcinogenic transformation. In the HPV viral life cycle, E7 disrupts the intimate association between cellular differentiation and proliferation in normal epithelium, allowing for viral replication in cells that would… CONTINUE READING
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