The human papillomavirus E7-E2 interaction mechanism in vitro reveals a finely tuned system for modulating available E7 and E2 proteins.

Abstract

Transcription of the human papillomavirus E7 oncoprotein is negatively controlled by the viral E2 protein, and loss of this repression leads to irreversible transformation and carcinogenesis. Here we show that interaction of the HPV16 E7 protein with the DNA binding domain of the E2 protein (E2C) leads to ionic strength-dependent hetero-oligomerization even… (More)
DOI: 10.1021/bi901415k

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@article{Smal2009TheHP, title={The human papillomavirus E7-E2 interaction mechanism in vitro reveals a finely tuned system for modulating available E7 and E2 proteins.}, author={Clara Smal and Diana E. Wetzler and Karina I Dantur and Luc{\'i}a B. Chemes and Maria Marta Garc{\'i}a-Alai and Mariano Dellarole and Leonardo G. Alonso and Kevin Gaston and Gonzalo de Prat-Gay}, journal={Biochemistry}, year={2009}, volume={48 50}, pages={11939-49} }