The human papillomavirus (HPV) 16 E2 protein induces apoptosis in the absence of other HPV proteins and via a p53-dependent pathway.

@article{Webster2000TheHP,
  title={The human papillomavirus (HPV) 16 E2 protein induces apoptosis in the absence of other HPV proteins and via a p53-dependent pathway.},
  author={Kenneth J Webster and Joanna L Parish and Maya J Pandya and Peter L. Stern and A. R. Clarke and Kevin Gaston},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 1},
  pages={87-94}
}
The human papillomavirus (HPV) E2 protein regulates viral gene expression and is also required for viral replication. HPV-transformed cells often contain chromosomally integrated copies of the HPV genome in which the viral E2 gene is disrupted. We have shown previously that re-expression of the HPV 16 E2 protein in HPV 16-transformed cells results in cell death via apoptosis. Here we show that the HPV 16 E2 protein can induce apoptosis in both HPV-transformed and non-HPV-transformed cell lines… CONTINUE READING

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