The human papilloma virus (HPV)-18 E6 oncoprotein physically associates with Tyk2 and impairs Jak-STAT activation by interferon-alpha.

@article{Li1999TheHP,
  title={The human papilloma virus (HPV)-18 E6 oncoprotein physically associates with Tyk2 and impairs Jak-STAT activation by interferon-alpha.},
  author={Shanshan Li and Sylvie Labrecque and Maria Cristina Gauzzi and Andrew R. Cuddihy and Andrew Hoi-Tao Wong and Sandra Pellegrini and Gregory J. Matlashewski and Antonis E. Koromilas},
  journal={Oncogene},
  year={1999},
  volume={18 42},
  pages={5727-37}
}
We have examined the effects of human papilloma virus (HPV) E6 proteins on interferon (IFN) signaling. Here we show that expression of the 'malignant' HPV-18 E6 in human HT1080 cells results in inhibition of Jak-STAT activation in response to IFN-alpha but not IFN-gamma. This inhibitory effect is not shared by the 'benign' HPV-11 E6. The DNA-binding and transactivation capacities of the transcription factor ISGF3 are diminished in cells expressing HPV-18 E6 after IFN-alpha treatment as a result… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 43 extracted citations

Similar Papers

Loading similar papers…