The human olfactory subgenome: from sequence to structure and evolution

  title={The human olfactory subgenome: from sequence to structure and evolution},
  author={Tania Fuchs and Gustavo Glusman and Shirley Horn-Saban and Doron Lancet and Yitzhak Pilpel},
  journal={Human Genetics},
Olfactory receptors (ORs) constitute the largest multigene family in multicellular organisms. Their evolutionary proliferation has been driven by the need to provide recognition capacity for millions of potential odorants with arbitrary chemical configurations. Human genome sequencing has provided a highly informative picture of the "olfactory subgenome", the repertoire of OR genes. We describe here an analysis of 224 human OR genes, a much larger number than hitherto systematically analyzed… CONTINUE READING

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 30 extracted citations

Smell with inspiration: the evolutionary significance of olfaction.

American journal of physical anthropology • 2010
View 4 Excerpts
Highly Influenced

On the dimensionality of olfactory space

Marcelo Magnasco, Andreas Keller, +3 authors Leslie. Vosshall
View 3 Excerpts


Publications referenced by this paper.
Showing 1-10 of 48 references

Distribution of olfactory receptor genes in the human genome

Nature Genetics • 1998
View 6 Excerpts
Highly Influenced

A genomic region encompassing a cluster of olfactory receptor genes and a myosin light chain kinase ( MYLK ) gene is duplicated on human chromosome regions 3 q 13q 21 and 3 p 13

V Brand-Arpon, S Rouquier, +5 authors D Giorgi
Genomics • 1999
View 6 Excerpts
Highly Influenced

Using CLUSTAL for multiple sequence alignments.

Methods in enzymology • 1996
View 3 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…