The human olfactory receptor repertoire

@article{Zozulya2001TheHO,
  title={The human olfactory receptor repertoire},
  author={Sergey Zozulya and Fernando Echeverri and Trieu Nguyen},
  journal={Genome Biology},
  year={2001},
  volume={2},
  pages={research0018.1 - research0018.12}
}
BackgroundThe mammalian olfactory apparatus is able to recognize and distinguish thousands of structurally diverse volatile chemicals. This chemosensory function is mediated by a very large family of seven-transmembrane olfactory (odorant) receptors encoded by approximately 1,000 genes, the majority of which are believed to be pseudogenes in humans.ResultsThe strategy of our sequence database mining for full-length, functional candidate odorant receptor genes was based on the high overall… 

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TLDR
Sequence and copy number polymorphisms in OR genes have been described, which may account for interindividual differences in odorant detection thresholds.
The human olfactory transcriptome
TLDR
An overview of expression levels of ORs and auxiliary genes in human olfactory epithelium is provided and a transcriptomic view of the entire OR repertoire is revealed, revealing a large number of over-expressed uncharacterized human non-receptor genes, providing a platform for future discovery.
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TLDR
It is found that humans have accumulated mutations that disrupt OR coding regions roughly 4-fold faster than any other species sampled, suggesting a human-specific process of OR gene disruption, likely due to a reduced chemosensory dependence relative to apes.
Characterization of Zebrafish Class C Olfactory Receptor Gene repertoire
TLDR
The genome datamining results directs towards the theory that the Class C olfactory receptors might function as a complex of two or more receptors like that of taste receptors.
Similar numbers but different repertoires of olfactory receptor genes in humans and chimpanzees.
TLDR
The number of OR genes and the fraction of pseudogenes in chimpanzees are very similar to those in humans, though macaques have considerably fewer OR genes, suggesting that the OR gene repertoires are in a phase of deterioration in both lineages.
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