The human myelin-basic-protein gene: chromosomal localization and RFLP analysis.

@article{Kamholz1987TheHM,
  title={The human myelin-basic-protein gene: chromosomal localization and RFLP analysis.},
  author={John A Kamholz and R. P. Spielman and K J Gogolin and William S. Modi and Steve O'Brien and Remo Lazzarini},
  journal={American journal of human genetics},
  year={1987},
  volume={40 4},
  pages={
          365-73
        }
}
With a human myelin-basic-protein (MBP) cDNA used as a probe, the human MBP gene has been mapped to chromosome region 18q22-q23 by a combination of Southern hybridization to a panel of somatic-cell hybrid DNAs and in situ hybridization to metaphase chromosomes. Restriction-fragment-length polymorphisms (RFLPs) have also been identified with this probe in human DNA, by means of the restriction enzymes BamHI, PvuII, and PstI. In studies of informative families, the alleles of the BamHI and PvuII… CONTINUE READING
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