The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs.

@article{Reid2003TheHM,
  title={The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs.},
  author={Glen Reid and Peter R Wielinga and Noam Zelcer and Ingrid van der Heijden and Annemieke J Kuil and Marcel de Haas and Jan Wijnholds and Piet Borst},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 16},
  pages={9244-9}
}
Prostaglandins are involved in a wide variety of physiological and pathophysiological processes, but the mechanism of prostaglandin release from cells is not completely understood. Although poorly membrane permeable, prostaglandins are believed to exit cells by passive diffusion. We have investigated the interaction between prostaglandins and members of the ATP-binding cassette (ABC) transporter ABCC [multidrug resistance protein (MRP)] family of membrane export pumps. In inside-out membrane… CONTINUE READING
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