The human multidrug resistance protein 4 (MRP4, ABCC4): functional analysis of a highly polymorphic gene.

@article{Abla2008TheHM,
  title={The human multidrug resistance protein 4 (MRP4, ABCC4): functional analysis of a highly polymorphic gene.},
  author={Nada Abla and Leslie W Chinn and Tsutomu Nakamura and Li Liu and Conrad C Huang and Susan J. Johns and Michiko Kawamoto and Doug Stryke and Travis R. Taylor and Thomas E. Ferrin and Kathleen M. Giacomini and Deanna L. Kroetz},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2008},
  volume={325 3},
  pages={859-68}
}
ABCC4 encodes multidrug resistance protein 4 (MRP4), a member of the ATP-binding cassette family of membrane transporters involved in the efflux of endogenous and xenobiotic molecules. The aims of this study were to identify single nucleotide polymorphisms of ABCC4 and to functionally characterize selected nonsynonymous variants. Resequencing was performed in a large ethnically diverse population. Ten nonsynonymous variants were selected for analysis of transport function based on allele… CONTINUE READING

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