The human multidrug resistance-associated protein functionally complements the yeast cadmium resistance factor 1.

@article{Tommasini1996TheHM,
  title={The human multidrug resistance-associated protein functionally complements the yeast cadmium resistance factor 1.},
  author={Roberto Tommasini and Raymond Evers and Esther Vogt and C Mornet and Guido J. R. Zaman and Alfred H Schinkel and Piet Borst and Enrico Martinoia},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 13},
  pages={6743-8}
}
A Saccharomyces cerevisiae strain with a disrupted yeast cadmium resistance factor (YCF1) gene (DTY168) is hypersensitive to cadmium. YCF1 resembles the human multidrug resistance-associated protein MRP (63% amino acid similarity), which confers resistance to various cytotoxic drugs by lowering the intracellular drug concentration. Whereas the mechanism of action of YCF1 is not known, MRP was recently found to transport glutathione S-conjugates across membranes. Here we show that expression of… CONTINUE READING

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