The human methyltransferase ZCCHC4 catalyses N6-methyladenosine modification of 28S ribosomal RNA

  title={The human methyltransferase ZCCHC4 catalyses N6-methyladenosine modification of 28S ribosomal RNA},
  author={Rita Pinto and Cathrine Broberg Vågb{\o} and Magnus E. Jakobsson and Yeji Kim and Marijke P. A. Baltissen and Marie-Françoise O'Donohue and Ulises H Guzm{\'a}n and Jędrzej M. Małecki and Jie Wu and Finn Kirpekar and Jesper Velgaard Olsen and Pierre-Emmanuel Gleizes and Michiel Vermeulen and Sebastian A. Leidel and Geir Slupphaug and P{\aa}l {\O}. Falnes},
  journal={Nucleic Acids Research},
  pages={830 - 846}
Abstract RNA methylations are essential both for RNA structure and function, and are introduced by a number of distinct methyltransferases (MTases). In recent years, N6-methyladenosine (m6A) modification of eukaryotic mRNA has been subject to intense studies, and it has been demonstrated that m6A is a reversible modification that regulates several aspects of mRNA function. However, m6A is also found in other RNAs, such as mammalian 18S and 28S ribosomal RNAs (rRNAs), but the responsible MTases… 

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