The human medial temporal lobe processes online representations of complex objects

@article{Barense2007TheHM,
  title={The human medial temporal lobe processes online representations of complex objects},
  author={Morgan D. Barense and David Gaffan and Kim S. Graham},
  journal={Neuropsychologia},
  year={2007},
  volume={45},
  pages={2963-2974}
}

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References

SHOWING 1-10 OF 72 REFERENCES
Specialization in the medial temporal lobe for processing of objects and scenes
TLDR
Oddity tasks administered to amnesic patients with either selective hippocampal damage or more extensive medial temporal damage provide compelling evidence that the human hippocampus and perirhinal cortex are critical to processes beyond long‐term declarative memory and may subserve spatial and object perception, respectively.
Functional Specialization in the Human Medial Temporal Lobe
Investigations of memory in rats and nonhuman primates have demonstrated functional specialization within the medial temporal lobe (MTL), a set of heavily interconnected structures including the
Intact visual discrimination of complex and feature-ambiguous stimuli in the absence of perirhinal cortex.
TLDR
Assessment of visual discrimination ability and visual discrimination learning in severely amnesic patients with large medial temporal lobe lesions that included complete lesions of perirhinal cortex indicates that perirHinal cortex is not needed for visual perception across a wide range of visual perceptual tasks.
Abnormal Categorization and Perceptual Learning in Patients with Hippocampal Damage
TLDR
Patients with selective hippocampal lesions were tested on simple categorization and perceptual learning of faces and virtual reality scenes, suggesting that stimulus type may be a more critical predictor of performance on memory tasks (declarative and nondeclarative) than previously thought.
Activating the medial temporal lobe during oddity judgment for faces and scenes.
TLDR
It is found that in healthy participants oddity judgment for novel trial-unique scenes, compared with face or size oddity, was associated with increased posterior hippocampus and parahippocampal cortex activity, and the perirhinal cortex, and possibly anterior hippocampus, may play a more generic role in the discrimination and processing of objects.
Visual presentation of novel objects and new spatial arrangements of objects differentially activates the medial temporal lobe subareas in humans
TLDR
A functional magnetic resonance imaging study to compare the medial temporal lobe responses to changes in object identity and spatial configurations of objects found evidence for the predicted distinction between hippocampal and perirhinal cortical activations, although part of the hippocampus was also activated by identification of novel objects.
Processing Objects at Different Levels of Specificity
TLDR
Object processing always activated the fusiform gyrus bilaterally, irrespective of the task, whereas the perirhinal cortex was only activated when the task required finer-grained discriminations.
...
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