The human medial temporal lobe processes online representations of complex objects

  title={The human medial temporal lobe processes online representations of complex objects},
  author={Morgan D. Barense and David Gaffan and Kim S. Graham},

Figures and Tables from this paper

Medial temporal lobe activity during complex discrimination of faces, objects, and scenes: Effects of viewpoint
Functional neuroimaging in healthy participants as they performed a version of the oddity discrimination task provides convergent evidence that the MTL is involved in processes beyond long‐term declarative memory and suggests a critical role for these structures in integrating complex features of faces, objects, and scenes into view‐invariant, abstract representations.
Human Medial Temporal Lobe Damage Can Disrupt the Perception of Single Objects
A combination of techniques is used to provide strong evidence that the perirhinal cortex subserves perception and suggests that the MTL perceptual-mnemonic debate cannot be dismissed on the basis of anatomy or a working memory impairment.
Visual discrimination performance, memory, and medial temporal lobe function
The pattern of performance suggested that patients encountered difficulty because working memory capacity was exceeded in the more difficult conditions such that performance needed to depend on retrieval from long-term memory.
Perception and the Medial Temporal Lobe: Evaluating the Current Evidence
Stimulus familiarity modulates functional connectivity of the perirhinal cortex and anterior hippocampus during visual discrimination of faces and objects
It is suggested that in order to benefit from stimulus familiarity, it is necessary to engage not only the perirhinal cortex and hippocampus, but also a network of regions known to represent semantic information.
Medial Temporal Lobe Damage Impairs Representation of Simple Stimuli
Findings indicate that MTL lesions subtly impair short-term maintenance of even simple stimuli, with performance reflecting not the complete loss of the maintained representation but rather a degradation or progressive drift of the representation over time.
Perirhinal Cortex Contributes to Accuracy in Recognition Memory and Perceptual Discriminations
The results indicate that declarative memory demands are not a prerequisite for a performance-related engagement of PRc and that the introduction of such declaratives memory demands in an otherwise closely matched perceptual task does not necessarily lead to an increase in PRc involvement.


Specialization in the medial temporal lobe for processing of objects and scenes
Oddity tasks administered to amnesic patients with either selective hippocampal damage or more extensive medial temporal damage provide compelling evidence that the human hippocampus and perirhinal cortex are critical to processes beyond long‐term declarative memory and may subserve spatial and object perception, respectively.
Functional Specialization in the Human Medial Temporal Lobe
Investigations of memory in rats and nonhuman primates have demonstrated functional specialization within the medial temporal lobe (MTL), a set of heavily interconnected structures including the
Intact visual discrimination of complex and feature-ambiguous stimuli in the absence of perirhinal cortex.
Assessment of visual discrimination ability and visual discrimination learning in severely amnesic patients with large medial temporal lobe lesions that included complete lesions of perirhinal cortex indicates that perirHinal cortex is not needed for visual perception across a wide range of visual perceptual tasks.
Abnormal Categorization and Perceptual Learning in Patients with Hippocampal Damage
Patients with selective hippocampal lesions were tested on simple categorization and perceptual learning of faces and virtual reality scenes, suggesting that stimulus type may be a more critical predictor of performance on memory tasks (declarative and nondeclarative) than previously thought.
Activating the medial temporal lobe during oddity judgment for faces and scenes.
It is found that in healthy participants oddity judgment for novel trial-unique scenes, compared with face or size oddity, was associated with increased posterior hippocampus and parahippocampal cortex activity, and the perirhinal cortex, and possibly anterior hippocampus, may play a more generic role in the discrimination and processing of objects.
Visual presentation of novel objects and new spatial arrangements of objects differentially activates the medial temporal lobe subareas in humans
A functional magnetic resonance imaging study to compare the medial temporal lobe responses to changes in object identity and spatial configurations of objects found evidence for the predicted distinction between hippocampal and perirhinal cortical activations, although part of the hippocampus was also activated by identification of novel objects.
Processing Objects at Different Levels of Specificity
Object processing always activated the fusiform gyrus bilaterally, irrespective of the task, whereas the perirhinal cortex was only activated when the task required finer-grained discriminations.