The human lysozyme promoter directs reporter gene expression to activated myelomonocytic cells in transgenic mice.

@article{Clarke1996TheHL,
  title={The human lysozyme promoter directs reporter gene expression to activated myelomonocytic cells in transgenic mice.},
  author={Steven W. Clarke and David Greaves and Lap Ping Chung and Peter Tree and Saimon Gordon},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 4},
  pages={1434-8}
}
The 5' region of the human lysozyme gene from -3500 to +25 was fused to a chloramphenicol acetyltransferase (CAT) reporter gene and three transgenic founder mice were obtained. All three transgenic lines showed the same pattern of CAT enzyme expression in adult mouse tissues that was consistent with the targeting of elicited, activated macrophages in tissues and developing and elicited granulocytes. In normal mice high CAT enzyme activity was found in the spleen, lung, and thymus, tissues rich… CONTINUE READING

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