The human lipid regulator, gemfibrozil bioconcentrates and reduces testosterone in the goldfish, Carassius auratus.

@article{Mimeault2005TheHL,
  title={The human lipid regulator, gemfibrozil bioconcentrates and reduces testosterone in the goldfish, Carassius auratus.},
  author={Caroline Mimeault and Amanda J Woodhouse and X S Miao and Chris D Metcalfe and Thomas Moon and Vance L. Trudeau},
  journal={Aquatic toxicology},
  year={2005},
  volume={73 1},
  pages={44-54}
}
Human and veterinarian pharmaceuticals have been detected in the aquatic environment for a number of years, but the potential for biological effects in exposed aquatic organism is only now being reported. The lipid regulator, gemfibrozil (GEM) is detected at microg/L concentrations in domestic wastewater and ng/L concentrations in surface waters. We investigated the uptake of GEM in goldfish (Carassius auratus) over a 96 h time period by measuring GEM in blood plasma using LC-MS/MS. Results… CONTINUE READING