The human lactoferrin-derived peptide hLF1-11 primes monocytes for an enhanced TLR-mediated immune response

@article{Does2010TheHL,
  title={The human lactoferrin-derived peptide hLF1-11 primes monocytes for an enhanced TLR-mediated immune response},
  author={A. van der Does and Sylvia J. P. Bogaards and Luigi Jonk and Marty Bernardus Franciscus Wulferink and Markwin Paul Velders and Peter H Nibbering},
  journal={BioMetals},
  year={2010},
  volume={23},
  pages={493-505}
}
Earlier we reported that the peptide corresponding to the first eleven N-terminal amino acids of human lactoferrin (hLF1-11) is active against multi-drug resistant pathogens in mice. The mechanisms underlying this anti-infective activity remain unclear. Since hLF1-11 is ineffective against pathogens at physiological salt concentrations and hLF1-11 directs differentiation of monocytes toward a macrophage subset with enhanced effector functions, we investigated the effects of hLF1-11 on human and… CONTINUE READING
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