The human kidney is a progesterone-metabolizing and androgen-producing organ.

@article{Quinkler2003TheHK,
  title={The human kidney is a progesterone-metabolizing and androgen-producing organ.},
  author={Marcus Quinkler and Ch Bumke-Vogt and Bernhard Meyer and Volker von Baehr and Wolfgang Oelkers and Sven Diederich},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2003},
  volume={88 6},
  pages={2803-9}
}
Progesterone (P) is a potent antagonist of the human mineralocorticoid receptor (MR) in vitro. We have previously demonstrated effective downstream metabolism of P in the kidney. This mechanism potentially protects the MR from P action. Here, we have investigated the expression and functional activity of steroidogenic enzymes in human kidney. RT-PCR analysis demonstrated the expression of 5 alpha-reductase type 1, 5 beta-reductase, aldo-keto-reductase (AKR) 1C1, AKR1C2, AKR1C3, 3 beta… CONTINUE READING

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