The human interleukin-6 receptor α chain gene is localized on chromosome 1 band q21

@article{Kluck2004TheHI,
  title={The human interleukin-6 receptor $\alpha$ chain gene is localized on chromosome 1 band q21},
  author={Petra M. C. Kluck and Joop Wiegant and Rumo P. M. Jansen and Marian W. J. Bolk and Anton K. Raap and Roelof Willemze and James E. Landegent},
  journal={Human Genetics},
  year={2004},
  volume={90},
  pages={542-544}
}
The human interleukin-6 receptor α chain (IL6Rα) gene was regionally mapped to chromosome 1 bridization probes, partially overlapping lambda clones encompassing 28 kb of the genomic region of the gene were used. These clones were isolated using a polymerase chain reaction (PCR)-generated fragment of the 3′ noncoding region of the gene. This localization confirms and extends the provisional assignment of the IL6Rα gene to chromosome 1, for which a panel of somatic cell hybrids was used. 
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References

SHOWING 1-10 OF 20 REFERENCES
Interleukin 4 is at 5q31 and interleukin 6 is at 7p15
TLDR
DNA probes to the human interleukin 4 and IL6 genes have been used for in situ hybridization to normal human chromosomes and Southern blot analysis of a series of mouse-human hybrid cell lines.
Functional murine interleukin 6 receptor with the intracisternal A particle gene product at its cytoplasmic domain. Its possible role in plasmacytomagenesis
TLDR
Two species of the cDNAs encoding murine IL-6-R have been cloned from a plasmacytoma cell line, P3U1, and BALB/c mouse spleen cDNA libraries, indicating that abnormal IL- 6-R lacking a normal cytoplasmic domain can function.
Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor.
TLDR
A complementary DNA encoding the human IL-6 receptor (IL-6-R) has now been isolated and consists of 468 amino acids, including a signal peptide of approximately 19 amino acids and a domain of approximately 90 amino acids that is similar to a domain in the immunoglobulin (Ig) superfamily.
Cytokine production by the bladder carcinoma cell line 5637: rapid analysis of mRNA expression levels using a cDNA-PCR procedure.
TLDR
This procedure proved to be a semiquantitative technique when compared to Northern blot analysis, and expression pattern was not altered after 12-O-tetradecanoyl-phorbol-13-acetate (TPA) stimulation of 5637 cells.
Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas
TLDR
It is reported that myeloma cells freshly isolated from patients produce BSF-2 and express its receptors, direct evidence that an autocrine loop is operating in oncogenesis of human myelomas.
Use of whole cosmid cloned genomic sequences for chromosomal localization by non-radioactive in situ hybridization
SummaryWe report a general procedure which allows the application of whole cosmid cloned genomic sequences for non-radioactive in situ hybridization. The presence of highly repetitive sequences, like
The biology of interleukin-6.
TLDR
Human IL-6 (BSF2) was originally identified as a factor in the culture supernatants of mitogen or antigen-stimulated peripheral mononuclear cells, which induced immunoglobulin production in Epstein Barr virus transformed B-cell lines or in Staphylococcus aureus Cowan 1 stimulated normal B cells.
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