The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling

@article{Ebina1985TheHI,
  title={The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling},
  author={Y. Ebina and L. Ellis and K. Jarnagin and M. Edery and W. Rutter},
  journal={Cell},
  year={1985},
  volume={40},
  pages={747-758}
}
A cloned approximately 5 kb cDNA (human placenta) contains the coding sequences for the insulin receptor. The nucleotide sequence predicts a 1382 amino acid precursor. The alpha subunit comprises the N-terminal portion of the precursor and contains a striking cysteine-rich "cross-linking" domain. The beta-subunit (the C-terminal portion of the precursor) contains a transmembrane domain and, in the intracellular region, the elements of a tyrosine phosphokinase: an ATP-binding site and a possible… Expand
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