The human insulin gene linked polymorphic region exhibits an altered DNA structure.

@article{HammondKosack1992TheHI,
  title={The human insulin gene linked polymorphic region exhibits an altered DNA structure.},
  author={Michael C. U. Hammond-Kosack and Beate Dobrinski and Rudi Lurz and Karen J. Docherty and Michael W. Kilpatrick},
  journal={Nucleic acids research},
  year={1992},
  volume={20 2},
  pages={
          231-6
        }
}
Regulation of transcription of the human insulin gene appears to involve a series of DNA sequences in the 5' region. Hypersensitivity to DNA structural probes has previously been demonstrated in regulatory regions of cloned genomic DNA fragments, and been correlated with gene activity. To investigate the structure of the DNA in the human insulin gene, bromoacetaldehyde and S1 nuclease were reacted with a supercoiled plasmid containing a 5kb genomic insulin fragment. Both probes revealed the… CONTINUE READING
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