The human immunodeficiency virus type 1 nef gene can to a large extent replace simian immunodeficiency virus nef in vivo.

@article{Kirchhoff1999TheHI,
  title={The human immunodeficiency virus type 1 nef gene can to a large extent replace simian immunodeficiency virus nef in vivo.},
  author={Frank Kirchhoff and Jan M{\"u}nch and Silke Carl and Nicole Stolte and Kerstin Maetz-Rensing and Dietmar Fuchs and Peter J. F. Ten Haaft and Jonathan Luke Heeney and Tomek Swigut and Jacek Skowronski and Christiane Stahl-Hennig},
  journal={Journal of virology},
  year={1999},
  volume={73 10},
  pages={8371-83}
}
The nef gene of the pathogenic simian immunodeficiency virus (SIV) 239 clone was replaced with primary human immunodeficiency virus type 1 (HIV-1) nef alleles to investigate whether HIV-1 Nef can substitute for SIV Nef in vivo. Initially, two rhesus macaques were infected with the chimeric viruses (Nef-SHIVs). Most of the nef alleles obtained from both animals predicted intact open reading frames. Furthermore, forms containing upstream nucleotide substitutions that enhanced expression of the… CONTINUE READING

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