The human immunodeficiency virus type 1 Vpr protein upregulates PVR via activation of the ATR-mediated DNA damage response pathway.

@article{Vassena2013TheHI,
  title={The human immunodeficiency virus type 1 Vpr protein upregulates PVR via activation of the ATR-mediated DNA damage response pathway.},
  author={Lia Vassena and Erica Giuliani and Giulia Matusali and {\'E}ric A Cohen and Margherita Doria},
  journal={The Journal of general virology},
  year={2013},
  volume={94 Pt 12},
  pages={2664-9}
}
Viral infection may induce the cell-surface expression of PVR (CD155) that, upon recognition by its cognate activating DNAM-1 receptor present on cytotoxic lymphocytes, may promote antiviral immune responses. Here we show that expression of the human immunodeficiency virus type 1 (HIV-1) Vpr protein in Jurkat T cells increases cell-surface and total PVR levels. Analysis of mutated Vpr variants indicated that Vpr uses the same protein surfaces, and hence probably the same mechanisms, to… CONTINUE READING
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