The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages

@article{Miller1994TheHI,
  title={The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages},
  author={Michael D. Miller and Maria Warmerdam and Itziar Gast{\'o}n and Warner C. Greene and Mark B. Feinberg},
  journal={The Journal of Experimental Medicine},
  year={1994},
  volume={179},
  pages={101 - 113}
}
Considerable controversy and uncertainty have surrounded the biological function of the Human Immunodeficiency Virus (HIV)-1 nef gene product. Initial studies suggested that this early, nonstructural viral protein functioned as a negative regulatory factor; thus, it was proposed to play a role in establishing or maintaining viral latency. In contrast, studies in Simian Immunodeficiency Virus (SIV)mac-infected rhesus monkeys have suggested that Nef is not a negative factor but rather plays a… CONTINUE READING
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