The human immunodeficiency virus: infectivity and mechanisms of pathogenesis.

@article{Fauci1988TheHI,
  title={The human immunodeficiency virus: infectivity and mechanisms of pathogenesis.},
  author={A S Fauci},
  journal={Science},
  year={1988},
  volume={239 4840},
  pages={
          617-22
        }
}
Infection with the human immunodeficiency virus (HIV) results in a profound immunosuppression due predominantly to a selective depletion of helper/inducer T lymphocytes that express the receptor for the virus (the CD4 molecule). HIV also has tropism for the brain leading to neuropsychiatric abnormalities. Besides inducing cell death, HIV can interfere with T4 cell function by various mechanisms. The monocyte serves as a reservoir for HIV and is relatively refractory to its cytopathic effects… CONTINUE READING

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