The human immune response to Plasmodium falciparum includes both antibodies that inhibit merozoite surface protein 1 secondary processing and blocking antibodies.

@article{Nwuba2002TheHI,
  title={The human immune response to Plasmodium falciparum includes both antibodies that inhibit merozoite surface protein 1 secondary processing and blocking antibodies.},
  author={Roseangela I. Nwuba and Olugbemiro Sodeinde and Chiaka I Anumudu and Yusuf O Omosun and Alexander B. Odaibo and Anthony A. Holder and Mark Nwagwu},
  journal={Infection and immunity},
  year={2002},
  volume={70 9},
  pages={5328-31}
}
Malaria merozoite surface protein 1 (MSP1) is cleaved in an essential step during erythrocyte invasion. The responses of children to natural malaria infection included antibodies that inhibit this cleavage and others that block the binding of these inhibitory antibodies. There was no correlation between the titer of the antibody to the 19-kDa fragment of MSP1 and its inhibitory activity. These findings have implications for the design of MSP1-based vaccines. 

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Genetic diversity in the C-terminus of merozoite surface protein 1 among Plasmodium knowlesi isolates from Selangor and Sabah Borneo, Malaysia.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases • 2017
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