The human hexokinase II gene promoter: functional characterization and detection of variants among patients with NIDDM


Hexokinase II (HKII) plays an important role in facilitating glucose uptake by skeletal muscle, heart, and adipose tissue in response to insulin. We have cloned and sequenced the proximal promoter region of the human HKII gene, determined the transcription start sites and screened the 2.0 kb of the proximal 5 ′ flanking region for variants in non-insulin… (More)
DOI: 10.1007/s001250050850


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