The human herpesvirus 8 chemokine receptor vGPCR triggers autonomous proliferation of endothelial cells.

@article{Grisotto2006TheHH,
  title={The human herpesvirus 8 chemokine receptor vGPCR triggers autonomous proliferation of endothelial cells.},
  author={Marcos G Grisotto and Alexandre Garin and Andrea P Martin and Kristian K. Jensen and Pokman Chan and Stuart C. Sealfon and Sergio A Lira},
  journal={The Journal of clinical investigation},
  year={2006},
  volume={116 5},
  pages={1264-73}
}
We have used a novel conditional transgenic system to study the mechanisms of angioproliferation induced by viral G protein-coupled receptor (vGPCR), the constitutively active chemokine receptor encoded by human herpesvirus 8 (HHV8, also known as Kaposi sarcoma herpesvirus). Using this system, we were able to control temporal expression of vGPCR and to monitor its expression in situ via the use of the surrogate marker LacZ. Upon treatment with doxycycline (DOX), cells expressing vGPCR and LacZ… CONTINUE READING