The human herpesvirus-8 ORF 57 gene and its properties.

  title={The human herpesvirus-8 ORF 57 gene and its properties.},
  author={Leonard J. Bello and Andrew J Davison and M A Glenn and Adrian Whitehouse and N. O. M. Rethmeier and Thomas F Schulz and J Barklie Clements},
  journal={The Journal of general virology},
  volume={80 ( Pt 12)},
Human herpesvirus-8 (HHV-8) is a gamma(2) lymphotropic herpesvirus associated with Kaposi's sarcoma, a major neoplasm of AIDS patients, and with other AIDS-related neoplasms. The HHV-8 ORF 57 gene is conserved throughout the herpesvirus family and has a herpes simplex virus type 1 homologue, IE63 (also termed ICP27), which is an essential regulatory protein and acts at both transcriptional and post-transcriptional levels. We show that, contrary to the published HHV-8 sequence, which predicts a… CONTINUE READING


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