The human genome contains many types of chimeric retrogenes generated through in vivo RNA recombination.

@article{Buzdin2003TheHG,
  title={The human genome contains many types of chimeric retrogenes generated through in vivo RNA recombination.},
  author={Anton Buzdin and Elena V Gogvadze and Elena Kovalskaya and Pavel Y. Volchkov and Svetlana V. Ustyugova and Anna Illarionova and Alexey Fushan and Tatiana G Vinogradova and Eugene D. Sverdlov},
  journal={Nucleic acids research},
  year={2003},
  volume={31 15},
  pages={4385-90}
}
L1 retrotransposons play an important role in mammalian genome shaping. In particular, they can transduce their 3'-flanking regions to new genomic loci or produce pseudogenes or retrotranscripts through reverse transcription of different kinds of cellular RNAs. Recently, we found in the human genome an unusual family of chimeric retrotranscripts composed of full-sized copies of U6 small nuclear RNAs fused at their 3' termini with 5'-truncated, 3'-poly(A)-tailed L1s. The chimeras were flanked by… CONTINUE READING

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