The human general co-factors.

@article{Kaiser1996TheHG,
  title={The human general co-factors.},
  author={Kim Kaiser and Michael Meisterernst},
  journal={Trends in biochemical sciences},
  year={1996},
  volume={21 9},
  pages={342-5}
}
The human general co-factors were discovered during biochemical fractionation of mammalian nuclear extracts in functional in vitro assays. They appear to act in concert with other co-activators that bind tightly to the TATA-binding protein and RNA polymerase II. Several co-factors have been shown to interact with general transcription factors, leading either to activation or repression of transcription. At least one subgroup of co-factors that enhance the effects of activators on transcription… CONTINUE READING

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