The human gene encoding SCYB9B, a putative novel CXC chemokine, maps to human chromosome 4q21 like the closely related genes for MIG (SCYB9) and INP10 (SCYB10)

@article{Erdel1998TheHG,
  title={The human gene encoding SCYB9B, a putative novel CXC chemokine, maps to human chromosome 4q21 like the closely related genes for MIG (SCYB9) and INP10 (SCYB10)},
  author={Martin Erdel and Andreas Laich and Gerd Utermann and Ernst R. Werner and Gabriele Werner-Felmayer},
  journal={Cytogenetic and Genome Research},
  year={1998},
  volume={81},
  pages={271 - 272}
}
Chemokines, a class of 8to 10-kDa basic proteins, attract and activate leukocytes. Various families have been subdivided due to the relative position of their conserved cysteine residues. Two of them, i.e. the CXC or ·-chemokines and CC or ßchemokines have been extensively studied. CXC chemokines, also called small inducible cytokine B subfamily (SCYB) according to the Human Gene Nomenclature Committee, are characterized by two pairs of cysteines separated by one amino acid. Further, they can… 

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References

SHOWING 1-9 OF 9 REFERENCES

Localization of the gene for the human MIG cytokine on chromosome 4q21 adjacent to INP10 reveals a chemokine "mini-cluster".

TLDR
It is demonstrated by pulsed field gel electrophoresis that MIG and INP10 are distant from the tight cluster of other CXC chemokine genes at 4q12-->q13, and determined that Mig and INp10 are oriented head to tail with their start codons separated by less than 16 kb.

Human chemokines: an update.

TLDR
Of considerable interest is the recent discovery that some chemokines function as HIV-suppressive factors by interacting with chemokine receptors which, together with CD4, were recognized as the binding sites for HIV-1.

Mig and IP‐10: CXC chemokines that target lymphocytes

  • J. Farber
  • Biology
    Journal of leukocyte biology
  • 1997
TLDR
RHuMig and rIP‐10 share additional activities, including inhibition of neovascularization, inhibition of hematopoietic progenitor cells, and anti‐tumor effects, and that, despite their similar activities assayed in vitro, Mig and IP‐10/Crg‐2 may serve non‐redundant functions in vivo.

Structure and chromosomal localization of the human stromal cell-derived factor 1 (SDF1) gene.

TLDR
Stromal cell-derived factors 1 alpha and 1 beta are small cytokines belonging to the intercrine CXC subfamily and originally isolated from a murine bone-marrow stroma cell line by the signal sequence trap method, and strong evolutionary conservation and unique chromosomal localization of the SDF1 gene suggest that they may have important functions distinct from those of other members of the interCrine family.

Cloning, structural analysis, and chromosomal localization of the human CSRP2 gene encoding the LIM domain protein CRP2.

TLDR
A human CSRP2 cDNA clone encoding a 193-amino-acid human CRP2 (hCRP2) protein with 96.4% amino acid sequence identity to the avian homolog is isolated.

A genetic selection for isolating cDNAs encoding secreted proteins.

Chemokines--chemotactic cytokines that mediate inflammation.

  • A. Luster
  • Biology
    The New England journal of medicine
  • 1998
TLDR
This review introduces the burgeoning family of cytokines, with special emphasis on their role in the pathophysiology of disease and their potential as targets for therapy.

Characterization of β-R1, a Gene That Is Selectively Induced by Interferon β (IFN-β) Compared with IFN-α*

TLDR
Induction of the β-R1 gene in fibrosarcoma cells and derivative mutant cells lacking components required for signaling by type I IFNs requires IFN-stimulated gene factor 3 plus an additional component, which is more efficiently formed on induction by IFn-β compared withIFN-α.

Localization of the human CXC chemokine subfamily on the long arm of chromosome 4 using radiation hybrids.

TLDR
Phylogenetic analyses of amino acid sequences revealed that SDF1 is the most divergent member and that the physically separated MIG-INP10 pair constitutes a distinct evolutionary lineage.