The human gamma-glutamyltransferase gene family

  title={The human gamma-glutamyltransferase gene family},
  author={Nora Heisterkamp and John Groffen and David Warburton and Tam P. Sneddon},
  journal={Human Genetics},
Assays for gamma-glutamyl transferase (GGT1, EC activity in blood are widely used in a clinical setting to measure tissue damage. The well-characterized GGT1 is an extracellular enzyme that is anchored to the plasma membrane of cells. There, it hydrolyzes and transfers γ-glutamyl moieties from glutathione and other γ-glutamyl compounds to acceptors. As such, it has a critical function in the metabolism of glutathione and in the conversion of the leukotriene LTC4 to LTD4. GGT deficiency… CONTINUE READING


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IdentiWcation of a human gamma-glutamyl cleaving enzyme related to, but distinct from, gamma-glutamyl transpeptidase

  • N Heisterkamp, E Rajpert-De Meyts, L Uribe, HJ Forman, J GroVen
  • Proc Natl Acad Sci USA
  • 1991
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