The human gallbladder secretes fibroblast growth factor 19 into bile: Towards defining the role of fibroblast growth factor 19 in the enterobiliary tract

@article{Zweers2012TheHG,
  title={The human gallbladder secretes fibroblast growth factor 19 into bile: Towards defining the role of fibroblast growth factor 19 in the enterobiliary tract},
  author={S.J.L.B. Zweers and K A C Booij and Mina Komuta and Tania A. Roskams and Dirk Joan Gouma and Peter L. M. Jansen and Frank G. Schaap},
  journal={Hepatology},
  year={2012},
  volume={55}
}
Fibroblast growth factor 19 (FGF19) plays a crucial role in the negative feedback regulation of bile salt synthesis. In the postprandial state, activation of ileal farnesoid X receptor (FXR) by bile salts results in transcriptional induction of FGF19 and elevation of circulating FGF19 levels. An intestinal‐liver axis of FGF19 signaling results in down‐regulation of bile salt synthesis. The aim of this study was to explore a broader signaling activity of FGF19 in organs engaged in the… 
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Potent stimulation of fibroblast growth factor 19 expression in the human ileum by bile acids
TLDR
FGF19 expression in human ileum is very highly responsive to BA, and changes in FGF19 induction are a potential mechanism involved in disorders of BA homeostasis.
Cynomolgus monkey gallbladder bile contains high concentrations of fibroblast growth factor 19
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To address the skeptical view of an endocrine factor appearing in an exocrine space, gallbladder bile from cynomolgus monkeys (Macaca fascicularis) is examined for the presence of FGF19 and the similar serum FGF 19 profile of the two species furthers the interest in using monkeys as a model to understand the potential dual endocrine/ exocrine roles of F GF19.
Upregulation of hepatic bile acid synthesis via fibroblast growth factor 19 is defective in gallstone disease but functional in overweight individuals
TLDR
Upregulation of hepatic bile acid synthesis via FGF 19 is defective in gallstone disease but functional in overweight individuals.
Finding fibroblast growth factor 19 during cholestasis: Does x mark the spot?
Metabolic Messengers: fibroblast growth factor 15/19
TLDR
The gut hormone FGF19 and its mouse orthologue Fgf15 are important mediators of the metabolic transition between the fasted and fed state and the putative therapeutic potential in areas of unmet medical need is discussed.
Role of interleukin‐30 as a modulator of transcription signaling in liver injury
TLDR
This study supports the functional link between KLB and gallstone disease, as suggested by Zweers et al. and suggests that intestinal hypomotility contributes to gallstone susceptibility in carriers of the KLB risk variant.
Effect of cholecystectomy on bile acid synthesis and circulating levels of fibroblast growth factor 19.
What is the cellular source of FGF 19 during chronic liver disease ?
Fibroblast Growth Factor 15/19: From Basic Functions to Therapeutic Perspectives
TLDR
Differences between mice and humans in the biology of FGF15/19 have to be considered for a successful translation from bench to bedside, with a special focus on regulation of production, morphogenic properties, hepatocyte growth, bile acid homeostasis, as well as actions on glucose, lipid, and energyHomeostasis.
Circulating FGF19 closely correlates with bile acid synthesis and cholestasis in patients with primary biliary cirrhosis
TLDR
Findings demonstrate that the regulation of BA synthesis in response to cholestasis is primarily controlled by circulating FGF19 and that underCholestatic conditions, the FGF 19-BA synthesis feedback mechanism remains intact.
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