The human gallbladder secretes fibroblast growth factor 19 into bile: Towards defining the role of fibroblast growth factor 19 in the enterobiliary tract

@article{Zweers2012TheHG,
  title={The human gallbladder secretes fibroblast growth factor 19 into bile: Towards defining the role of fibroblast growth factor 19 in the enterobiliary tract},
  author={S.J.L.B. Zweers and K A C Booij and Mina Komuta and Tania A. Roskams and Dirk Joan Gouma and Peter L. M. Jansen and Frank G. Schaap},
  journal={Hepatology},
  year={2012},
  volume={55}
}
Fibroblast growth factor 19 (FGF19) plays a crucial role in the negative feedback regulation of bile salt synthesis. In the postprandial state, activation of ileal farnesoid X receptor (FXR) by bile salts results in transcriptional induction of FGF19 and elevation of circulating FGF19 levels. An intestinal‐liver axis of FGF19 signaling results in down‐regulation of bile salt synthesis. The aim of this study was to explore a broader signaling activity of FGF19 in organs engaged in the… 
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