The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia.

@article{Fuchs2001TheHF,
  title={The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia.},
  author={Uta Fuchs and George Rehkamp and Oskar A Haas and Robert K Slany and Monica Konig and Sophie Bojesen and Rainer Bohle and Christine Damm-Welk and W. D. Ludwig and Jochen Harbott and Arndt Borkhardt},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 15},
  pages={
          8756-61
        }
}
We have cloned a fusion partner of the MLL gene at 11q23 and identified it as the gene encoding the human formin-binding protein 17, FBP17. It maps to chromosome 9q34 centromeric to ABL. The gene fusion results from a complex chromosome rearrangement that was resolved by fluorescence in situ hybridization with various probes on chromosomes 9 and 11 as an ins(11;9)(q23;q34)inv(11)(q13q23). The rearrangement resulted in a 5'-MLL/FBP17-3' fusion mRNA. We retrovirally transduced murine-myeloid… CONTINUE READING

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