The human factors YY1 and LSF repress the human immunodeficiency virus type 1 long terminal repeat via recruitment of histone deacetylase 1.

@article{Coull2000TheHF,
  title={The human factors YY1 and LSF repress the human immunodeficiency virus type 1 long terminal repeat via recruitment of histone deacetylase 1.},
  author={Jason J Coull and Fabio Romerio and J M Sun and Janet Volker and Katherine M. Galvin and James R. Davie and Yan Shi and Ulla Hansen and David M Margolis},
  journal={Journal of virology},
  year={2000},
  volume={74 15},
  pages={6790-9}
}
Enigmatic mechanisms restore the resting state in activated lymphocytes following human immunodeficiency virus type 1 (HIV-1) infection, rarely allowing persistent nonproductive infection. We detail a mechanism whereby cellular factors could establish virological latency. The transcription factors YY1 and LSF cooperate in repression of transcription from the HIV-1 long terminal repeat (LTR). LSF recruits YY1 to the LTR via the zinc fingers of YY1. The first two zinc fingers were observed to be… CONTINUE READING

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