The human eye expresses high levels of CB1 cannabinoid receptor mRNA and protein

  title={The human eye expresses high levels of CB1 cannabinoid receptor mRNA and protein},
  author={Anna Porcella and Cristina Maxia and Gian Luigi Gessa and Luca Pani},
  journal={European Journal of Neuroscience},
We used reverse transcriptase polymerase chain reaction to detect the expression of the central and peripheral cannabinoid receptors (CB1 and CB2, respectively) mRNA, and Western blotting to show the presence of the CB1 protein in subregions of the human eye. CB2 mRNA transcripts were undetectable, while levels of CB1 mRNA were significantly expressed in the human retina (25.8 ± 2.46%), ciliary body (210 ± 11.55%) and iris (62.7 ± 5.94%) when compared with those of the normalizing reference… 

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