The human epidermal differentiation complex: cornified envelope precursors, S100 proteins and the ‘fused genes’ family

@article{Kypriotou2012TheHE,
  title={The human epidermal differentiation complex: cornified envelope precursors, S100 proteins and the ‘fused genes’ family},
  author={Magdalini Kypriotou and Marcel Huber and Daniel Hohl},
  journal={Experimental Dermatology},
  year={2012},
  volume={21}
}
Abstract: The skin is essential for survival and protects our body against biological attacks, physical stress, chemical injury, water loss, ultraviolet radiation and immunological impairment. The epidermal barrier constitutes the primordial frontline of this defense established during terminal differentiation. During this complex process proliferating basal keratinocytes become suprabasally mitotically inactive and move through four epidermal layers (basal, spinous, granular and layer, stratum… 
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TLDR
It is shown that the calcium peak specific for the stratum granulosum, which is the site where loricrin and the LCE1&2 families are synthesized, is reduced during ageing, which means the resulting cornified envelope in old skin has an extensively changed composition on the molecular level compared to young skin.
Keratinocyte Differentiation and Epigenetics
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