The human epidermal differentiation complex: cornified envelope precursors, S100 proteins and the ‘fused genes’ family

@article{Kypriotou2012TheHE,
  title={The human epidermal differentiation complex: cornified envelope precursors, S100 proteins and the ‘fused genes’ family},
  author={Magdalini Kypriotou and Marcel Huber and Daniel Hohl},
  journal={Experimental Dermatology},
  year={2012},
  volume={21}
}
Abstract: The skin is essential for survival and protects our body against biological attacks, physical stress, chemical injury, water loss, ultraviolet radiation and immunological impairment. The epidermal barrier constitutes the primordial frontline of this defense established during terminal differentiation. During this complex process proliferating basal keratinocytes become suprabasally mitotically inactive and move through four epidermal layers (basal, spinous, granular and layer, stratum… 
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TLDR
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References

SHOWING 1-10 OF 160 REFERENCES
Differentially expressed late constituents of the epidermal cornified envelope
TLDR
A new gene cluster in the epidermal differentiation complex at human 1q21 is reported encoding a family of 18 proteins that are substrates for epidermally transglutaminases that are modulate barrier activity over the surface of the animal, in a manner analogous to that proposed for the well characterized cornified envelope precursors, the small proline-rich proteins.
SPRR4, a novel cornified envelope precursor: UV-dependent epidermal expression and selective incorporation into fragile envelopes.
TLDR
The results show for the first time that UV-induced cornification is accompanied by qualitative changes in CE precursor assembly, which indicates that SPRR4 is part of an adaptive tissue response to environmental stress, which is likely to compensate for UV induced impairment of the epidermal barrier function.
Late cornified envelope family in differentiating epithelia--response to calcium and ultraviolet irradiation.
The late cornified envelope (LCE) gene cluster within the epidermal differentiation complex on human chromosome one (mouse chromosome three) contains multiple conserved genes encoding stratum-corneum
Identification of trichohyalin-like 1, an s100 fused-type protein selectively expressed in hair follicles.
TLDR
Two SFTP members are recently identified in healthy human skin and it is suggested that different SFTPs might have overlapping functions, underline the importance of molecular characterization of members of the complete gene family.
Large-scale identification of human genes implicated in epidermal barrier function
TLDR
The first analysis of the transcriptome of human GKs is presented, purified from healthy epidermis by an original approach, to increase the present knowledge of genes responsible for the formation of the skin barrier and suggest new candidates for genodermatoses of unknown origin.
Cornulin, a new member of the "fused gene" family, is expressed during epidermal differentiation.
TLDR
It is reported that human cornulin mRNA is expressed primarily in the upper layers of differentiated squamous tissues including the epidermis, and cornulin is a new member of the "fused gene" family, does not appear to be a precursor of the cornified cell envelope by itself, and is a marker of late epidermal differentiation.
Protein composition of cornified cell envelopes of epidermal keratinocytes.
TLDR
The amino acid compositions of isolated CEs are determined and then modelled in terms of linear combinations of the candidate proteins, showing that stratum corneum CEs have a loricrin content of 65-70% (w/w) in human, and 80-85% in mouse.
Hornerin is a component of the epidermal cornified cell envelopes
  • J. Henry, Chiung-Yueh Hsu, M. Simon
  • Biology
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2011
TLDR
It is demonstrated that HRNR is a component of cornified cell envelopes of human epidermis, and its reduced expression in AD may contribute to the epidermal barrier defect observed in the disease.
Epithelial barrier function: assembly and structural features of the cornified cell envelope.
TLDR
The current understanding of CE structure, a possible mechanism of its assembly, and various disorders that cause a defective barrier are described.
...
1
2
3
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5
...