The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding.

@article{Stuchell2004TheHE,
  title={The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding.},
  author={Melissa D Stuchell and Jennifer E. Garrus and Barbara M{\"u}ller and Kirsten M. Stray and Sanaz Ghaffarian and Rena S McKinnon and Hans-Georg Kr{\"a}usslich and Scott G. Morham and Wesley I. Sundquist},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 34},
  pages={36059-71}
}
Efficient human immunodeficiency virus type 1 (HIV-1) budding requires an interaction between the PTAP late domain in the viral p6(Gag) protein and the cellular protein TSG101. In yeast, Vps23p/TSG101 binds both Vps28p and Vps37p to form the soluble ESCRT-I complex, which functions in sorting ubiquitylated protein cargoes into multivesicular bodies. Human cells also contain ESCRT-I, but the VPS37 component(s) have not been identified. Bioinformatics and yeast two-hybrid screening methods were… CONTINUE READING
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