The human embryo, but not its yolk sac, generates lympho-myeloid stem cells: mapping multipotent hematopoietic cell fate in intraembryonic mesoderm.

@article{Tavian2001TheHE,
  title={The human embryo, but not its yolk sac, generates lympho-myeloid stem cells: mapping multipotent hematopoietic cell fate in intraembryonic mesoderm.},
  author={Manuela Tavian and Catherine Robin and Laure Coulombel and Bruno P{\'e}ault},
  journal={Immunity},
  year={2001},
  volume={15 3},
  pages={487-95}
}
We have traced emerging hematopoietic cells along human early ontogeny by culturing embryonic tissue rudiments in the presence of stromal cells that promote myeloid and B cell differentiation, and by assaying T cell potential in the NOD-SCID mouse thymus. Hematogenous potential was present inside the embryo as early as day 19 of development in the absence of detectable CD34+ hematopoietic cells, and spanned both lymphoid and myeloid lineages from day 24 in the splanchnopleural mesoderm and… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 51 references

Identification of human T-lymphoid pro(1998). Molecular identity of hematopoietic precursor cells emerging genitor cells in CD34 CD38low and CD34 CD38 subsets

C. Robin, A. Bennaceur-Griscelli, +7 authors L. Coulombel
1999
View 5 Excerpts
Highly Influenced

In vitro development of murine T the second day of incubation

C. P. Liu, R. Auerbach
Contrib. Embryol • 1991
View 2 Excerpts
Highly Influenced

Hematopoiesis in young

G. W. Bartelmez
1940
View 2 Excerpts
Highly Influenced

Hematopoiesis in youngviously described in Tavian et al . ( 1999 ) according to Carnegie human embryos

G. W. Bartelmez
Am . J . Anat . • 1940
View 2 Excerpts
Highly Influenced

poietic cells in the early human embryo

C. J. Marshall, C. Kinnon, A. J. Thrasher
Blood • 2000

tiation factor (MGDF; Amgen), 5 ng/ml IL2 (Diaclone), 10 ng/ml

M. F. de Bruijn, N. A. Speck, M. C. Peeters, E. Dzierzak
2000
View 1 Excerpt

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