The human dynamin-related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter-membrane space.

@article{Olichon2002TheHD,
  title={The human dynamin-related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter-membrane space.},
  author={Aur{\'e}lien Olichon and Laurent Jean Emorine and Eric Descoins and Laetitia Pelloquin and Laetitia Brichese and Nicole Gas and Emmanuelle Guillou and C{\'e}cile Delettre and Annie Valette and Christian P. Hamel and Bernard Ducommun and Guy Lenaers and Pascale B{\'e}lenguer},
  journal={FEBS letters},
  year={2002},
  volume={523 1-3},
  pages={171-6}
}
Mutations in the OPA1 gene are associated with autosomal dominant optic atrophy. OPA1 encodes a dynamin-related protein orthologous to Msp1 of Schizosaccharomyces pombe and Mgm1p of Saccharomyces cerevisiae, both involved in mitochondrial morphology and genome maintenance. We present immuno-fluorescence and biochemical evidences showing that OPA1 resides in the mitochondria where it is imported through its highly basic amino-terminal extension. Proteolysis experiments indicate that OPA1 is… CONTINUE READING

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