The human decatenation checkpoint.

  title={The human decatenation checkpoint.},
  author={Paula B. Deming and Cheryl A. Cistulli and Hui Zhao and Paul R. Graves and Helen Piwnica-Worms and Richard S. Paules and C. Stephen Downes and William K. Kaufmann},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={98 21},
Chromatid catenation is actively monitored in human cells, with progression from G(2) to mitosis being inhibited when chromatids are insufficiently decatenated. Mitotic delay was quantified in normal and checkpoint-deficient human cells during treatment with ICRF-193, a topoisomerase II catalytic inhibitor that prevents chromatid decatenation without producing topoisomerase-associated DNA strand breaks. Ataxia telangiectasia (A-T) cells, defective in DNA damage checkpoints, showed normal… CONTINUE READING
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