The human cytomegalovirus major immediate-early distal enhancer region is required for efficient viral replication and immediate-early gene expression.

@article{Meier2000TheHC,
  title={The human cytomegalovirus major immediate-early distal enhancer region is required for efficient viral replication and immediate-early gene expression.},
  author={Jeffery L. Meier and Jonathan A. Pruessner},
  journal={Journal of virology},
  year={2000},
  volume={74 4},
  pages={1602-13}
}
The human cytomegalovirus (HCMV) major immediate-early (MIE) genes, encoding IE1 p72 and IE2 p86, are activated by a complex enhancer region (base positions -65 to -550) that operates in a cell type- and differentiation-dependent manner. The expression of MIE genes is required for HCMV replication. Previous studies analyzing functions of MIE promoter-enhancer segments suggest that the distal enhancer region variably modifies MIE promoter activity, depending on cell type, stimuli, or state of… CONTINUE READING

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