The human cytomegalovirus UL55 (gB) and UL75 (gH) glycoprotein ligands initiate the rapid activation of Sp1 and NF-kappaB during infection.

@article{Yurochko1997TheHC,
  title={The human cytomegalovirus UL55 (gB) and UL75 (gH) glycoprotein ligands initiate the rapid activation of Sp1 and NF-kappaB during infection.},
  author={Andrew D Yurochko and Ellen S. Hwang and Lynn Rasmussen and Susan Keay and Lenore Pereira and E. S. Huang},
  journal={Journal of virology},
  year={1997},
  volume={71 7},
  pages={5051-9}
}
The cellular transcription factors Sp1 and NF-kappaB were upregulated shortly after the binding of purified live or UV-inactivated human cytomegalovirus (HCMV) to the cell surface. The rapid time frame of transcription factor induction is similar to that seen in other systems in which cellular factors are induced following receptor-ligand engagement. This similarity suggested that a cellular receptor-viral ligand interaction might be involved in Sp1 and NF-kappaB activation during the earliest… CONTINUE READING

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