The human cytomegalovirus UL36 gene controls caspase-dependent and -independent cell death programs activated by infection of monocytes differentiating to macrophages.

@article{McCormick2010TheHC,
  title={The human cytomegalovirus UL36 gene controls caspase-dependent and -independent cell death programs activated by infection of monocytes differentiating to macrophages.},
  author={A. Louise McCormick and Linda J. Roback and Devon Livingston-Rosanoff and Courtney St Clair},
  journal={Journal of virology},
  year={2010},
  volume={84 10},
  pages={5108-23}
}
The cellular protease caspase-8 activates extrinsic apoptosis and also functions to promote monocyte-to-macrophage differentiation. Differentiation-induced alterations to antiviral caspase-8-dependent cell death pathways are unclear. Here, we show THP-1 monocyte-to-macrophage differentiation alters the specific cell death pathways activated in response to human cytomegalovirus (HCMV) infection. Employing viruses with mutations in UL36, the gene that encodes the viral inhibitor of caspase-8… CONTINUE READING

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Control of apoptosis by human cytomegalovirus.

Current topics in microbiology and immunology • 2008

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