The human cornea has a high incidence of acquired chromosome abnormalities

  title={The human cornea has a high incidence of acquired chromosome abnormalities},
  author={Mark J. Pettenati and A. J. Sweatt and Patrick E. Lantz and Constance A. Stanton and James Reynolds and P Nagesh Rao and Richard Marc Davis},
  journal={Human Genetics},
Structurally and functionally, the human cornea is a highly specialized tissue. The corneal stromal collagen matrix is uniquely transparent and yet maintains a mechanically tough and chemically impermeable barrier between the eye and environment. We report for the first time that stromal keratocytes of the human cornea show cytogenetic abnormalities with a frequency that is unprecedented among normal tissues. The abnormalities are acquired, clonal and nonclonal, primarily aneuploid in nature… CONTINUE READING
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Significance of the clonal and sporadic chromosome abnormalities in nonneoplastic renal tissue

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