The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L.

@article{Tomecki2010TheHC,
  title={The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L.},
  author={Rafał Tomecki and Maiken S. Kristiansen and S\oren Lykke-Andersen and Aleksander Chlebowski and Katja M Larsen and Roman J Szczesny and Karolina Drążkowska and Agnieszka Pastula and Jens Skorstengaard Andersen and Piotr P. Stępień and Andrzej Dziembowski and Torben Heick Jensen},
  journal={The EMBO journal},
  year={2010},
  volume={29 14},
  pages={2342-57}
}
The eukaryotic RNA exosome is a ribonucleolytic complex involved in RNA processing and turnover. It consists of a nine-subunit catalytically inert core that serves a structural function and participates in substrate recognition. Best defined in Saccharomyces cerevisiae, enzymatic activity comes from the associated subunits Dis3p (Rrp44p) and Rrp6p. The former is a nuclear and cytoplasmic RNase II/R-like enzyme, which possesses both processive exo- and endonuclease activities, whereas the latter… CONTINUE READING